Optimal robust two-stage designs for genome-wide association studies.

Abstract excerpt

Optimal robust two-stage designs for genome-wide association studies are proposed using the maximum of the recessive, additive and dominant linear trend test statistics. These designs combine cost-saving two-stage genotyping with robustness against misspecification of the genetic model and are much more efficient than designs based on a single model specific test statistic in detecting multiple loci with...

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