Article
Global tests for linkage.
Biometrical journal. Biometrische Zeitschrift - 1 Feb 2009
el Galta Rachid, van Houwelingen Hans C, Houwing-Duistermaat Jeanine J
Abstract excerpt
To test for global linkage along a genome or in a chromosomal region, the maximum over the marker locations of mean alleles shared identical by descent of affected relative pairs, Z(max), can be used. Feingold et al. (1993) derived a Gaussian approximation to the distribution of the Z(max). As an alternative we propose to sum over the observed marker locations along the chromosomal region of interest. Two test...
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