Article
Model-free sib-pair linkage analysis: combining full-sib and half-sib pairs.
Genetic epidemiology - 1 Jul 2000
Schaid D J, Elston R C, Tran L, Wilson A F
Abstract excerpt
When sampling full-sibs for linkage studies, half-sibs are often available. Not only are half-sibs convenient to sample, but they can sometimes offer greater power than full-sibs. We propose a method to combine the information from full-sibs and half-sibs into a single test for linkage. This method is based on the Haseman and Elston [1972] method of regressing the squared trait-difference for a pair of sibs...
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