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Article

Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair.

The Journal of biological chemistry - 21 Jan 2000

Horton J K, Prasad R, Hou E, Wilson S H

Abstract excerpt

Using a plasmid-based uracil-containing DNA substrate, we found that the long patch base excision repair (BER) activity of a wild-type mouse fibroblast extract was partially inhibited by an antibody to DNA polymerase beta (beta-pol). This suggests that beta-pol participates in long patch BER, in addition to single-nucleotide BER. In single-nucleotide BER, the deoxyribose phosphate (dRP) in the abasic site is...

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Identifiers

PMID: 10636928
DOI: 10.1074/jbc.275.3.2211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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