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Article

Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities.

Oncogene - 4 Apr 2002

Fréchet Mathilde, Canitrot Yvan, Bieth Anne, Dogliotti Eugenia, Cazaux Christophe, Hoffmann Jean-Sébastien

Abstract excerpt

DNA polymerase beta (Pol beta) is an error-prone enzyme which has been found to be overexpressed in several human tumors. By using a couple of recombinant CHO cells differing only from the exogenous expression of Pol beta, we showed here that cells overexpressing Pol beta are much more sensitive to IR treatments by increasing apoptosis. We also found that the surviving cells displayed an hypermutator phenotype...

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Identifiers

PMID: 11948415
DOI: 10.1038/sj.onc.1205295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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