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Article

Role of DNA polymerase theta in tolerance of endogenous and exogenous DNA damage in mouse B cells.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2006

Ukai Akiko, Maruyama Takako, Mochizuki Shigenobu, Ouchida Rika, Masuda Keiji, Kawamura Kiyoko, Tagawa Masatoshi, Kinoshita Kazuo, Sakamoto Akemi, Tokuhisa Takeshi, O-Wang Jiyang

Abstract excerpt

DNA polymerase theta (Poltheta) is a family A polymerase that contains an intrinsic helicase domain. To investigate the function of Poltheta in mammalian cells, we have inactivated its polymerase activity in CH12 mouse B lymphoma cells by targeted deletion of the polymerase core domain that contains the catalytic aspartic acid residue. Compared to parental CH12 cells, mutant cells devoid of Poltheta polymerase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16436048
DOI: 10.1111/j.1365-2443.2006.00922.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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