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Article

Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency.

DNA repair - 1 Apr 2007

Horton Julie K, Wilson Samuel H

Abstract excerpt

Single-base lesions in DNA are repaired predominantly by base excision repair (BER). DNA polymerase beta (pol beta) is the polymerase of choice in the preferred single-nucleotide BER pathway. The characteristic phenotype of mouse fibroblasts with a deletion of the pol beta gene is moderate hypersensitivity to monofunctional alkylating agents, e.g., methyl methanesulfonate (MMS). Increased sensitivity to MMS is...

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Neoplasm

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Share to Poly(ADP-ribose) Polymerases

Source

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Identifiers

PMID: 17113833
DOI: 10.1016/j.dnarep.2006.10.016
PMCID: PMC1911606

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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