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Article

Requirement of mammalian DNA polymerase-beta in base-excision repair.

Nature - 11 Jan 1996

Sobol R W, Horton J K, Kühn R, Gu H, Singhal R K, Prasad R, Rajewsky K, Wilson S H

Abstract excerpt

Synthesis of DNA by DNA polymerase-beta is distributive on single-stranded DNA templates, but short DNA gaps with a 5' PO4 in the gap are filled processively to completion. In vitro studies have suggested a role of beta-polymerase in different types of DNA repair. However, the significance of these studies to the in vivo role of beta-polymerase has remained unclear. Because genetic studies are essential for...

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PMID: 8538772
DOI: 10.1038/379183a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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