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Article

Allelic imbalance and mutations of the PTEN gene in ovarian cancer.

International journal of cancer - 15 Jan 2000

Saito M, Okamoto A, Kohno T, Takakura S, Shinozaki H, Isonishi S, Yasuhara T, Yoshimura T, Ohtake Y, Ochiai K, Yokota J, Tanaka T

Abstract excerpt

The PTEN/MMAC1/TEP1 tumor-suppressor gene, which maps to chromosome 10q23.3, is mutated and homozygously deleted in a variety of human tumors, including endometrioid-type ovarian tumors. We examined 33 primary ovarian cancers and 3 ovarian borderline tumors for allelic imbalance (AI) of the 10q23.3 region using 5 polymorphic markers, including an insertion/deletion-type polymorphic marker identified in intron 4...

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Share to Chromosomes, Human, Pair 10
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Phosphoric Monoester Hydrolases

Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 10629071

Genes

PTEN
TEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Allelic imbalance and mutations of the PTEN gene in ovarian cancer.PMID 10629071Read ↗

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