Article
Common genetic changes between endometriosis and ovarian cancer.
Gynecologic and obstetric investigation - 1 Jan 2000
Obata K, Hoshiai H
Abstract excerpt
We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the other histological subtypes. Somatic PTEN mutations were detected in seven (21%) endometrioid cancers and the mutation in all informative cases was accompanied by loss of the wild-type allele. One mucinous cancer...
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