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Article

Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.

Cancer research - 15 May 1998

Obata K, Morland S J, Watson R H, Hitchcock A, Chenevix-Trench G, Thomas E J, Campbell I G

Abstract excerpt

Epithelial ovarian cancer comprises three major histological subtypes (serous, mucinous, and endometrioid), and it is becoming clear that the developmental pathways for these subtypes are fundamentally different. In particular, endometrioid ovarian cancers probably arise by the malignant transformation of ectopic endometrial implants called endometriosis and not the ovarian surface epithelium. The PTEN/MMAC gene...

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Share to Chromosomes, Human, Pair 10
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

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Source

Identifiers

PMID: 9605750

Genes

PTEN

Provenance

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Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.PMID 9605750Read ↗

PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.Semantic proximity Read ↗

Allelic imbalance and mutations of the PTEN gene in ovarian cancer.Semantic proximity Read ↗

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Allelic imbalance and mutations of thePTEN gene in ovarian cancerSemantic proximity Read ↗

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas.Semantic proximity Read ↗

Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.Semantic proximity Read ↗

PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations.Semantic proximity Read ↗

Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles.Semantic proximity Read ↗

Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.Semantic proximity Read ↗

PTEN/MMAC1 mutations in endometrial cancers.Semantic proximity Read ↗

Patterns of loss of heterozygosity at 10q23.3 and microsatellite instability in endometriosis, atypical endometriosis, and ovarian carcinoma arising in association with endometriosis.Semantic proximity Read ↗

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