Article
Chromosome 11 allele imbalance and clinicopathological correlates in ovarian tumours.
British journal of cancer - 1 Aug 1995
Gabra H, Taylor L, Cohen B B, Lessels A, Eccles D M, Leonard R C, Smyth J F, Steel C M
Abstract excerpt
Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epithelial ovarian cancers (EOCs). Forty EOCs (85%) showed allele imbalance at one or more loci, and in...
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