Article
Chromosome 11 allele imbalance and clinicopathological correlates in ovarian tumours.
British journal of cancer - 1 Aug 1995
Gabra H, Taylor L, Cohen B B, Lessels A, Eccles D M, Leonard R C, Smyth J F, Steel C M
Abstract excerpt
Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours,...
Topics
- Adenocarcinoma
- Adenofibroma
- Alleles
- Cell Differentiation
- Chromosomes, Human, Pair 11
- Cohort Studies
- Consensus Sequence
- DNA, Neoplasm
- DNA, Satellite
- Female
- Gene Deletion
- Granulosa Cell Tumor
- Heterozygote
- Humans
- Mixed Tumor, Mesodermal
- Ovarian Neoplasms
- Polymorphism, Genetic
- Teratoma