Article

Allelic imbalance and mutations of thePTEN gene in ovarian cancer

2000-01-15

Abstract excerpt

The PTEN/MMAC1/TEP1 tumor-suppressor gene, which maps to chromosome 10q23.3, is mutated and homozygously deleted in a variety of human tumors, including endometrioid-type ovarian tumors. We examined 33 primary ovarian cancers and 3 ovarian borderline tumors for allelic imbalance (AI) of the 10q23.3 region using 5 polymorphic markers, including an insertion/deletion-type polymorphic marker identified in intron 4 of...

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Literature Corpus work: f9058ecb-2aa3-51d1-a01c-508f320aeccd
DOI: 10.1002/(sici)1097-0215(20000115)85:2%3c160::aid-ijc2%3e3.0.co;2-5

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