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Article

PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines.

International journal of cancer - 15 Jan 2001

Kondo K, Yao M, Kobayashi K, Ota S, Yoshida M, Kaneko S, Baba M, Sakai N, Kishida T, Kawakami S, Uemura H, Nagashima Y, Nakatani Y, Hosaka M

Abstract excerpt

Extensive allelotyping studies have implicated several tumor-suppressor loci on chromosomes 3p, 5q, 6q, 8p, 9pq, 10q, 11q, 14q, 17p, 18q and 19p in human kidney tumorigenesis. The PTEN (also called MMAC1 and TEP1) gene, a candidate tumor suppressor located at chromosome 10q23.3, is mutated in a variety of sporadic malignancies as well as in patients with Cowden disease. To investigate the potential role of the...

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Share to Carcinoma, Renal Cell
Share to Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

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Source

Identifiers

PMID: 11146448
DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1034>3.0.co;2-s

Genes

PTEN
TEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines.PMID 11146448Read ↗

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Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping.Semantic proximity Read ↗

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Germline PTEN mutation Cowden syndrome: an underappreciated form of hereditary kidney cancer.Semantic proximity Read ↗

PTEN Gene Alterations in Lymphoid NeoplasmsSemantic proximity Read ↗

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