Article
Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors.
Genes, chromosomes & cancer - 1 Nov 1998
Halachmi N, Halachmi S, Evron E, Cairns P, Okami K, Saji M, Westra W H, Zeiger M A, Jen J, Sidransky D
Abstract excerpt
The PTEN (MMAC1/TEP1) tumor suppressor gene was recently isolated and mapped to human chromosome band 10q23. Homozygous deletions and mutations of PTEN were observed in cell lines and sporadic cancers of the breast, kidney, and central nervous system. Germline mutations in PTEN were recently found in Cowden disease, an autosomal dominant inherited syndrome, previously mapped to chromosome bands 10q22-23. This...
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