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Article

PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors.

Japanese journal of cancer research : Gann - 1 Apr 1999

Kawamura N, Nagai H, Bando K, Koyama M, Matsumoto S, Tajiri T, Onda M, Fujimoto J, Ueki T, Konishi N, Shiba T, Emi M

Abstract excerpt

Allelic loss of loci on chromosome 10q occurs frequently in hepatocellular carcinomas. Somatic mutations of the PTEN/MMAC1 gene on this chromosome at 10q23 were recently identified in sporadic cancers of the uterus, brain, prostate and breast. To investigate the potential role of PTEN/MMAC1 gene in the genesis of hepatocellular carcinomas, we examined 96 tumors for allelic loss on 10q and also for subtle...

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Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Germ-Line Mutation

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Share to Loss of Heterozygosity

Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

Source

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Identifiers

PMID: 10363579
DOI: 10.1111/j.1349-7006.1999.tb00763.x
PMCID: PMC5926086

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors.PMID 10363579Read ↗

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