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Article

Mutations in the PTEN tumor gene and risk of endometriosis: a case-control study.

Human reproduction (Oxford, England) - 1 Feb 2014

Govatati Suresh, Kodati Vijaya Lakshmi, Deenadayal Mamata, Chakravarty Baidyanath, Shivaji Sisinthy, Bhanoori Manjula

Abstract excerpt

STUDY QUESTION: Are mutations in the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene associated with endometriosis? SUMMARY ANSWER: Loss of heterozygosity (LOH) at the 10q23.3 locus, PTEN somatic mutations and changes in the levels and distribution of proteins in the PTEN-PI3K/Akt signal transduction pathway are associated with endometriosis. WHAT IS KNOWN ALREADY: Endometriosis has a strong...

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Identifiers

PMID: 24154570
DOI: 10.1093/humrep/det387

Genes

PTEN

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Association of genetic variations in phosphatase and tensin homolog (PTEN) gene with polycystic ovary syndrome in South Indian women: a case control study.Semantic proximity Read ↗

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