Article
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness.
The Journal of biological chemistry - 18 Apr 2008
Vinge Leif Erik, von Lueder Thomas G, Aasum Ellen, Qvigstad Eirik, Gravning Jørgen A, How Ole-Jakob, Edvardsen Thor, Bjørnerheim Reidar, Ahmed M Shakil, Mikkelsen Birthe W, Oie Erik, Attramadal Toril, Skomedal Tor, Smiseth Otto A, Koch Walter J, Larsen Terje S, Attramadal Håvard
Abstract excerpt
G protein-coupled receptor kinase-2 and -3 (GRK2 and GRK3) in cardiac myocytes catalyze phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by their carboxyl-terminal pleckstrin homology domain. Although GRK2 has been extensively investigated, the function of cardiac GRK3 remains unknown. Thus, in this study cardiac function of GRK3 was investigated in...
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