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Article

Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 1996

Rockman H A, Choi D J, Rahman N U, Akhter S A, Lefkowitz R J, Koch W J

Abstract excerpt

Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase-5 (GRK5), a serine/threonine kinase most abundantly expressed in the heart compared with other tissues. Animals overexpressing GRK5 showed marked beta-adrenergic receptor desensitization in both the anesthetized and conscious state compared with nontransgenic control mice, while the contractile response to...

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Source

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Identifiers

PMID: 8790438
DOI: 10.1073/pnas.93.18.9954
PMCID: PMC38536

Genes

GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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