Article
Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor.
Clinical and translational science - 1 Sept 2008
Chan Tung O, Funakoshi Hajime, Song Jianliang, Zhang Xue-Qian, Wang JuFang, Chung Paul H, DeGeorge Brent R, Li Xue, Zhang Jin, Herrmann David E, Diamond Maura, Hamad Eman, Houser Steven R, Koch Walter J, Cheung Joseph Y, Feldman Arthur M
Abstract excerpt
In the heart, adenosine binds to pharmacologically distinct G-protein-coupled receptors (A(1)-R, A(2A)-R, and A(3)-R). While the role of A(1)- and A(3)-Rs in the heart has been clarified, the effect of genetically manipulating the A(2A)-R has not been defined. Thus, we created mice overexpressing a cardiac-restricted A(2A)-R transgene. Mice with both low (Lo) and high (Hi) levels of A(2A)-R overexpression...
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