Article
The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.
The Journal of clinical investigation - 1 Jun 2003
O'Connell Timothy D, Ishizaka Shinji, Nakamura Akihiro, Swigart Philip M, Rodrigo M C, Simpson Gregory L, Cotecchia Susanna, Rokosh D Gregg, Grossman William, Foster Elyse, Simpson Paul C
Abstract excerpt
Catecholamines and alpha(1)-adrenergic receptors (alpha(1)-ARs) cause cardiac hypertrophy in cultured myocytes and transgenic mice, but heart size is normal in single KOs of the main alpha(1)-AR subtypes, alpha(1A/C) and alpha(1B). Here we tested whether alpha(1)-ARs are required for developmental cardiac hypertrophy by generating alpha(1A/C) and alpha(1B) double KO (ABKO) mice, which had no cardiac alpha(1)-AR...
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