Article
Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice.
Circulation - 21 Nov 2006
Lu Huanzhang, Fedak Paul W M, Dai Xiaojing, Du Changqing, Zhou Yu-Qing, Henkelman Mark, Mongroo Perry S, Lau Arthur, Yamabi Hideaki, Hinek Aleksander, Husain Mansoor, Hannigan Gregory, Coles John G
Abstract excerpt
BACKGROUND: Although numerous signaling pathways are known to be activated in experimental cardiac hypertrophy, the molecular basis of the hypertrophic response inherent in human heart diseases remains largely unknown. Integrin-linked kinase (ILK) is a multifunctional protein kinase that physically links beta-integrins with the actin cytoskeleton, suggesting a potential mechanoreceptor role. METHODS AND RESULTS:...
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