Article
Engineering yeast chromosomal telomeres with a bacteriophage system.
Nature communications - 19 May 2026
Deng Weiqin, Li Yanyan, Shao Yangyang, Zhao Ronglin, Zhou Fan, Zhong Li, Liu Wang, Wang Tao, He Ting, Zhang Siying, Chen Huilin, Man Xin, Hu Can, Fang Ping, Huang Yongping, Meng Xiangzhou, Zhou Jin-Qiu, Deng Zixin, Xue Xiaoli, Qin Zhongjun
Abstract excerpt
All eukaryotes, including yeast, plants, animals and humans, possess linear chromosomes. The conserved eukaryotic telomere-telomerase systems, originated and evolved over 1 billion years, protect the chromosomal ends and regulate critical physiological functions through complex networks. In this study, we replace the endogenous eukaryotic telomeres in the single-chromosome yeast Saccharomyces cerevisiae with the...
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