The adaptive molecular landscape of reprogrammed telomeric sequences

Abstract excerpt

Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequences are difficult to gauge from extant species. Here, we reprogrammed multiple yeast lines to human-like telomeric repeats to unveil their molecular and fitness response to novel telomeres. Initially, the exchange of...

Topics

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• DNA Damage
• Evolution, Molecular
• Genetic Variation
• Genomic Instability
• Mutation
• Saccharomyces cerevisiae
• Telomere
• Telomere-Binding Proteins

Identifiers and source

Literature Corpus work

42265daf-800a-5dab-85b5-a75d2e072fa9

DOI

10.1101/2025.06.24.661269