The adaptive molecular landscape of reprogrammed telomeric sequences.

Abstract excerpt

Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequences are difficult to gauge from extant species. Here, we engineer multiple yeast lines to human-like telomeric repeats to unveil their molecular and fitness response to reprogrammed telomeres. Initially, the exchange...

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