Diverse karyotypic abnormalities of the c <i>-myc</i> locus associated with c <i>-myc</i> dysregulation and tumor progression in multiple myeloma

Abstract excerpt

Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in 19 of 20 MM cell lines and approximately 50% of advanced primary MM tumors. These abnormalities include unusual and complex translocations and insertions that often juxtapose myc...

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