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Article

The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans.

Nature communications - 7 May 2024

Maura Francesco, Coffey David G, Stein Caleb K, Braggio Esteban, Ziccheddu Bachisio, Sharik Meaghen E, Du Megan T, Tafoya Alvarado Yuliza, Shi Chang-Xin, Zhu Yuan Xiao, Meermeier Erin W, Morgan Gareth J, Landgren Ola, Bergsagel P Leif, Chesi Marta

Abstract excerpt

Multiple myeloma (MM) is a heterogeneous disease characterized by frequent MYC translocations. Sporadic MYC activation in the germinal center of genetically engineered Vk*MYC mice is sufficient to induce plasma cell tumors in which a variety of secondary mutations are spontaneously acquired and selected over time. Analysis of 119 Vk*MYC myeloma reveals recurrent copy number alterations, structural variations,...

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Share to Cell Transformation, Neoplastic
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Multiple Myeloma

Share to Mutagenesis, Insertional

Share to NF-kappa B

Share to Proto-Oncogene Proteins c-myc

Share to Translocation, Genetic

Source

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Identifiers

PMID: 38714690
DOI: 10.1038/s41467-024-48091-w
PMCID: PMC11076575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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