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Article

Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors

15 Nov 2001

Abstract excerpt

Rearrangements of the c-myc oncogene have been found in most plasmacytomas induced in mice and human myeloma cell lines (HMCLs) analyzed so far. However, neither induced mouse plasmacytomas nor HMCLs represent relevant models for human multiple myeloma (MM). To evaluate the incidence of c-myc rearrangements in human plasma cell dyscrasias, sets of probes were generated to allow direct assessment of c-myc...

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PMID: 11698294
DOI: 10.1182/blood.v98.10.3082

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