Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes.

Cancer genetics and cytogenetics - 1 May 2007

Sáez Borja, Martín-Subero José I, Lahortiga Idoya, Largo Cristina, Larrayoz María J, Odero María D, Prosper Felipe, Cigudosa Juan C, Siebert Reiner, Calasanz María J

Abstract excerpt

The simultaneous occurrence of two different translocations affecting both alleles of the IGH gene has rarely been reported in multiple myeloma. In such a case, two different oncogenes might become transcriptionally deregulated. To investigate this hypothesis, we have characterized the plasma cell leukemia cell line SK-MM2 and a primary myeloma both carrying simultaneous IGH-FGFR3/MMSET and IGH-CCND1 fusions as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Banding
Share to Chromosome Painting

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin D

Share to Cyclins

Share to Histone-Lysine N-Methyltransferase

Share to Immunoglobulin Heavy Chains

Share to Multiple Myeloma

Share to Receptor, Fibroblast Growth Factor, Type 3

Source

Identifiers

PMID: 17498561
DOI: 10.1016/j.cancergencyto.2006.12.009

Genes

IGH
CCND1
FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes.PMID 17498561Read ↗

In multiple myeloma, 14q32 translocations are nonrandom chromosomal fusions driving high expression levels of the respective partner genesSemantic proximity Read ↗

Chromosome translocations in multiple myeloma.Semantic proximity Read ↗

Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with changes in transcriptional profiles.Semantic proximity Read ↗

Diverse karyotypic abnormalities of the c <i>-myc</i> locus associated with c <i>-myc</i> dysregulation and tumor progression in multiple myelomaSemantic proximity Read ↗

The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression.Semantic proximity Read ↗

The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid TranscriptsSemantic proximity Read ↗

Imaging flow cytometry-based multiplex FISH for three IGH translocations in multiple myelomaSemantic proximity Read ↗

A potential role for centrosomal deregulation within IgH translocation-positive myeloma.Semantic proximity Read ↗

Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogeneticsSemantic proximity Read ↗

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3.Semantic proximity Read ↗

Kinase domain activation through gene rearrangement in multiple myeloma.Semantic proximity Read ↗

Frequent upregulation of <i>MYC</i> in plasma cell leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.