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Article

OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus.

Leukemia research - 1 Dec 2009

Våtsveen Thea Kristin, Tian Erming, Kresse Stine H, Meza-Zepeda Leonardo A, Gabrea Ana, Glebov Oleg, Dai Hong Yan, Sundan Anders, Kuehl W Michael, Børset Magne

Abstract excerpt

Multiple myeloma can be classified into hyperdiploid (HRD) (with 48-74 chromosomes) and non-hyperdiploid tumors (usually with immunoglobulin heavy chain translocations). The OH-2 human myeloma cell line (HMCL) retains the same HRD genotype as the primary tumor, with extra copies of chromosomes 3, 7, 15, 19, and 21. Both OH-2 and primary cells have a complex secondary translocation in which the IGK 3' enhancer is...

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Share to Diploidy
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, myc

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin kappa-Chains

Share to MafB Transcription Factor

Share to Multiple Myeloma

Share to Translocation, Genetic

Source

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Identifiers

PMID: 19395026
DOI: 10.1016/j.leukres.2009.03.001
PMCID: PMC6944273

Genes

IGK
MAFB
MYC
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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