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Article

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma.

Blood - 1 Jul 2005

Bergsagel P Leif, Kuehl W Michael, Zhan Fenghuang, Sawyer Jeffrey, Barlogie Bart, Shaughnessy John

Abstract excerpt

Two oncogenic pathways have been hypothesized for multiple myeloma (MM) and premalignant monoclonal gammopathy of undetermined significance (MGUS) tumors: a nonhyperdiploid pathway associated with a high prevalence of IgH translocations and a hyperdiploid pathway associated with multiple trisomies of 8 chromosomes. Cyclin D1, D2, or D3 expression appears to be increased and/or dysregulated in virtually all MM...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15755896
DOI: 10.1182/blood-2005-01-0034
PMCID: PMC1895118

Genes

CCND1
CCND2
CCND3
MAF
MAFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma.PMID 15755896Read ↗

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Early Genetic Events Provide the Basis for a Clinical Classification of Multiple MyelomaSemantic proximity Read ↗

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Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.Semantic proximity Read ↗

Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression ProfilingSemantic proximity Read ↗

Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myelomaSemantic proximity Read ↗

Molecular pathogenesis of multiple myeloma and its premalignant precursorSemantic proximity Read ↗

Genomic complexity of multiple myeloma and its clinical implications.Semantic proximity Read ↗

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The varied distribution and impact of RAS codon and other key DNA alterations across the translocation cyclin D subgroups in multiple myeloma.Semantic proximity Read ↗

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