Article
Chromosome translocations in multiple myeloma.
Oncogene - 10 Sept 2001
Bergsagel P L, Kuehl W M
Abstract excerpt
Multiple myeloma (MM), a malignant tumor of somatically mutated, isotype-switched plasma cells (PC), usually arises from a common benign PC tumor called Monoclonal Gammopathy of Undetermined Significance (MGUS). MM progresses within the bone marrow, and then to an extramedullary stage from which MM cell lines are generated. The incidence of IgH translocations increases with the stage of disease: 50% in MGUS,...
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