The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of <i>MAFB</i>: a molecular and genetic analysis of the chromosomal breakpoint

Abstract excerpt

Chromosomal translocations of the immunoglobulin heavy chain (IgH) gene region at 14q32 are regularly involved in B lymphoid malignancies; they may initiate transformation either by deregulation of existing (proto) oncogenes or creation of new hybrid genes with transforming properties. Previously, we reported a reciprocal novel translocation, t(14;20)(q32;q12), found in the myeloma cell line UM3. In this cell...

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