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Article

Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation.

The Journal of biological chemistry - 7 Jan 2000

Wilkinson B M, Tyson J R, Reid P J, Stirling C J

Abstract excerpt

The translocation of secretory polypeptides into and across the membrane of the endoplasmic reticulum (ER) occurs at the translocon, a pore-forming structure that orchestrates the transport and maturation of polypeptides at the ER membrane. Recent data also suggest that misfolded or unassembled polypeptides exit the ER via the translocon for degradation by the cytosolic ubiquitin/proteasome pathway. Sec61p is a...

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Identifiers

PMID: 10617647
DOI: 10.1074/jbc.275.1.521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation.PMID 10617647Read ↗

The engagement of Sec61p in the ER dislocation process.Semantic proximity Read ↗

Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.Semantic proximity Read ↗

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.Semantic proximity Read ↗

Ssh1p determines the translocation and dislocation capacities of the yeast endoplasmic reticulum.Semantic proximity Read ↗

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.Semantic proximity Read ↗

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation.Semantic proximity Read ↗

Sss1p is required to complete protein translocon activation.Semantic proximity Read ↗

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.Semantic proximity Read ↗

A striking quality control subcompartment in Saccharomyces cerevisiae: the endoplasmic reticulum-associated compartment.Semantic proximity Read ↗

Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae.Semantic proximity Read ↗

The exocyst subunit Sec3 is regulated by a protein quality control pathway.Semantic proximity Read ↗

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.Semantic proximity Read ↗

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