Article
Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation.
The EMBO journal - 1 Aug 1997
Pilon M, Schekman R, Römisch K
Abstract excerpt
Degradation of misfolded secretory proteins has long been assumed to occur in the lumen of the endoplasmic reticulum (ER). Recent evidence, however, suggests that such proteins are instead degraded by proteasomes in the cytosol, although it remains unclear how the proteins are transported out of the ER. Here we provide the first genetic evidence that Sec61p, the pore-forming subunit of the protein translocation...
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