Article
Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.
The Journal of biological chemistry - 5 Dec 2008
Willer Martin, Forte Gabriella M A, Stirling Colin J
Abstract excerpt
Misfolded proteins in the endoplasmic reticulum (ER) are exported to the cytosol for degradation by the proteasome in a process known as ER-associated degradation (ERAD). CPY* is a well characterized ERAD substrate whose degradation is dependent upon the Hrd1 complex. However, although the functions of some of the components of this complex are known, the nature of the protein dislocation channel remains obscure....
Topics
- Carboxypeptidases
- Cell Membrane
- Endoplasmic Reticulum
- Genotype
- Membrane Proteins
- Membrane Transport Proteins
- Models, Genetic
- Mutation
- Oligonucleotides
- Plasmids
- Protein Binding
- Protein Transport
- SEC Translocation Channels
- Saccharomyces cerevisiae