Article
The exocyst subunit Sec3 is regulated by a protein quality control pathway.
The Journal of biological chemistry - 15 Sept 2017
Kampmeyer Caroline, Karakostova Antonina, Schenstrøm Signe M, Abildgaard Amanda B, Lauridsen Anne-Marie, Jourdain Isabelle, Hartmann-Petersen Rasmus
Abstract excerpt
Exocytosis involves fusion of secretory vesicles with the plasma membrane, thereby delivering membrane proteins to the cell surface and releasing material into the extracellular space. The tethering of the secretory vesicles before membrane fusion is mediated by the exocyst, an essential phylogenetically conserved octameric protein complex. Exocyst biogenesis is regulated by several processes, but the mechanisms...
Topics
- Deubiquitinating Enzymes
- Endocytosis
- Endopeptidases
- Enzyme Inhibitors
- Exocytosis
- Gene Deletion
- HSP70 Heat-Shock Proteins
- Microscopy, Electron, Transmission
- Models, Biological
- Mutation