Article
Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.
Molecular biology of the cell - 1 Dec 1998
Pilon M, Römisch K, Quach D, Schekman R
Abstract excerpt
The evolutionarily conserved Sec61 protein complex mediates the translocation of secretory proteins into the endoplasmic reticulum. To investigate the role of Sec61p, which is the main subunit of this complex, we generated recessive, cold-sensitive alleles of sec61 that encode stably expressed pr...
Topics
- Adenosine Triphosphate
- Base Sequence
- Biological Transport, Active
- DNA Primers
- Endoplasmic Reticulum
- Fungal Proteins
- Genes, Fungal
- Heat-Shock Proteins
- Intracellular Membranes
- Membrane Proteins
- Membrane Transport Proteins
- Mutation
- Phenotype
- Protein Binding
- Protein Precursors
- SEC Translocation Channels
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins