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Article

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.

Molecular biology of the cell - 1 Dec 1998

Pilon M, Römisch K, Quach D, Schekman R

Abstract excerpt

The evolutionarily conserved Sec61 protein complex mediates the translocation of secretory proteins into the endoplasmic reticulum. To investigate the role of Sec61p, which is the main subunit of this complex, we generated recessive, cold-sensitive alleles of sec61 that encode stably expressed proteins with strong defects in translocation. The stage at which posttranslational translocation was blocked was probed...

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Source

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Identifiers

PMID: 9843581
DOI: 10.1091/mbc.9.12.3455
PMCID: PMC25656

Genes

SEC63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.PMID 9843581Read ↗

Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation.Semantic proximity Read ↗

Sss1p is required to complete protein translocon activation.Semantic proximity Read ↗

Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP.Semantic proximity Read ↗

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.Semantic proximity Read ↗

The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons.Semantic proximity Read ↗

Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.Semantic proximity Read ↗

The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.Semantic proximity Read ↗

Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.Semantic proximity Read ↗

The engagement of Sec61p in the ER dislocation process.Semantic proximity Read ↗

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation.Semantic proximity Read ↗

Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.Semantic proximity Read ↗

Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence.Semantic proximity Read ↗

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