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Article

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.

The EMBO journal - 15 Jan 2001

Young B P, Craven R A, Reid P J, Willer M, Stirling C J

Abstract excerpt

The translocation of secretory polypeptides into the endoplasmic reticulum (ER) occurs at the translocon, a pore-forming structure that orchestrates the transport and maturation of polypeptides at the ER membrane. In yeast, targeting of secretory precursors to the translocon can occur by two distinct pathways that are distinguished by their dependence upon the signal recognition particle (SRP). The SRP-dependent...

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Identifiers

PMID: 11226176
DOI: 10.1093/emboj/20.1.262
PMCID: PMC140194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.PMID 11226176Read ↗

Signal sequences specify the targeting route to the endoplasmic reticulum membrane.Semantic proximity Read ↗

The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons.Semantic proximity Read ↗

Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP.Semantic proximity Read ↗

Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation.Semantic proximity Read ↗

Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.Semantic proximity Read ↗

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.Semantic proximity Read ↗

Targeting and translocation of proteins to the endoplasmic reticulum at a glanceSemantic proximity Read ↗

J domain co-chaperone specificity defines the role of BiP during protein translocation.Semantic proximity Read ↗

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation.Semantic proximity Read ↗

The Sec63p J-domain is required for ERAD of soluble proteins in yeast.Semantic proximity Read ↗

Interaction of Kar2p and Sls1p is required for efficient co-translational translocation of secreted proteins in the yeast Yarrowia lipolytica.Semantic proximity Read ↗

Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER.Semantic proximity Read ↗

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