Article
Sss1p is required to complete protein translocon activation.
The Journal of biological chemistry - 15 Oct 2010
Wilkinson Barrie M, Brownsword Judith K, Mousley Carl J, Stirling Colin J
Abstract excerpt
Protein translocation across the endoplasmic reticulum membrane occurs at the Sec61 translocon. This has two essential subunits, the channel-forming multispanning membrane protein Sec61p/Sec61α and the tail-anchored Sss1p/Sec61γ, which has been proposed to "clamp" the channel. We have analyzed the function of Sss1p using a series of domain mutants and found that both the cytosolic and transmembrane clamp domains...
Topics
- Amino Acid Sequence
- Endoplasmic Reticulum
- Membrane Transport Proteins
- Molecular Sequence Data
- Mutation
- Protein Structure, Tertiary
- Protein Transport
- SEC Translocation Channels
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins