Article
Ssh1p determines the translocation and dislocation capacities of the yeast endoplasmic reticulum.
Developmental cell - 1 Sept 2001
Wilkinson B M, Tyson J R, Stirling C J
Abstract excerpt
Sec61p is required both for protein translocation and dislocation across the membrane of the endoplasmic reticulum (ER). However, the cellular role of the Sec61p homolog Ssh1p has not been clearly defined. We show that deltassh1 mutant cells have strong defects in both SRP-dependent and -independent translocation. Moreover, these cells were also found to be induced for the unfolded protein response and to be...
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