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Article

p53 and survival in early onset breast cancer: analysis of gene mutations, loss of heterozygosity and protein accumulation.

European journal of cancer (Oxford, England : 1990) - 1 Aug 1999

Gentile M, Bergman Jungeström M, Olsen K E, Söderkvist P, Wingren S

Abstract excerpt

The p53 protein has proven to be central in tumorigenesis by its cell cycle regulatory properties and both gene mutations and protein accumulation have been associated with poor prognosis in breast cancer. The present study was undertaken to investigate the prognostic significance of gene mutations, p53 protein accumulation and of loss of heterozygosity (LOH) at the TP53 locus in young (age < 37 years) breast...

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Identifiers

PMID: 10615230
DOI: 10.1016/s0959-8049(99)00121-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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