Article
Biophenotypes and survival of BRCA1 and TP53 deleted breast cancer in young women.
Breast cancer research and treatment - 1 Mar 2001
Querzoli P, Albonico G, di Iasio M G, Ferretti S, Rinaldi R, Cariello A, Pedriali M, Matteuzzi M, Maestri I, Nenci I
Abstract excerpt
The aim of this study was to examine the loss of heterozygosity (LOH) of BRCA1 (17q21) and TP53 (17p13.1) in early-onset breast cancer patients; to correlate biopathological characteristics with molecular alterations; and to investigate the survival of LOH-related cancers. BRCA1 and TP53 LOH were evaluated in 78 early-onset breast cancers (< or = 40 years, Group 1) and 80 patients with age > 55 years (Group 2)....
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