Mutations in the p53 tumor suppressor gene and early onset breast cancer.

doi:10.4161/cbt.1.1.37

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Article

Mutations in the p53 tumor suppressor gene and early onset breast cancer.

Cancer biology & therapy - 1 Jan 2000

Lai Hong, Lin Lin, Nadji Mehrdad, Lai Shenghan, Trapido Edward, Meng Lou

Abstract excerpt

Among breast cancer patients p53 gene mutation is associated with a poor prognosis. Young women with breast cancer are more likely than older women to have a poor prognosis, but whether p53 gene mutation plays a role in breast cancer in young women is not clear. This study identified 199 breast cancer patients and tested the hypothesis that p53 gene mutation was associated with early onset breast cancer. Patients...

Topics

Adult
Age of Onset
Aged
Breast Neoplasms
Carcinoma
Codon
DNA Mutational Analysis
DNA, Neoplasm
Exons
Female
Genes, p53
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Mutation

Mutation, Missense

Neoplasm Proteins

Retrospective Studies

Source

Open in PubMed

Identifiers

PMID: 12170762
DOI: 10.4161/cbt.1.1.37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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