Feedback phosphorylation of the yeast a-factor receptor requires activation of the downstream signaling pathway from G protein through mitogen-activated protein kinase.

Abstract excerpt

The two yeast pheromone receptors, the a and alpha-factor receptors, share many functional similarities: both G protein-coupled receptors couple to the same downstream signal transduction pathway, and both receptors undergo feedback regulation involving increased phosphorylation on their C-terminal domains in response to ligand challenge. The present work, which focuses on the signaling mechanism controlling this...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endocytosis
• Share to Feedback
• Share to GTP-Binding Protein beta Subunits