Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway.

Abstract excerpt

In the Saccharomyces cerevisiae pheromone response pathway, the Gbetagamma complex activates downstream responses by an unknown mechanism involving a MAP kinase cascade, the PAK-like kinase Ste20, and a Rho family GTPase, Cdc42. Here we show that Gbetagamma must remain membrane-associated after r...

Topics

• Adaptor Proteins, Signal Transducing
• Amino Acid Sequence
• Carrier Proteins
• Cell Cycle Proteins
• Crosses, Genetic
• Fungal Proteins
• GTP Phosphohydrolases
• GTP-Binding Proteins
• Genotype
• Guanine Nucleotide Exchange Factors
• Intracellular Signaling Peptides and Proteins
• MAP Kinase Kinase Kinases
• Mating Factor
• Molecular Sequence Data