Article
The pheromone receptors inhibit the pheromone response pathway in Saccharomyces cerevisiae by a process that is independent of their associated G alpha protein.
Genetics - 1 Dec 1993
Hirsch J P, Cross F R
Abstract excerpt
Dominant mutations at the DAF2 locus confer resistance to the cell-cycle arrest that normally occurs in MATa cells exposed to alpha-factor. One of these alleles, DAF2-2, has also been shown to suppress the constitutive signaling phenotype of null alleles of the gene encoding the alpha subunit of...
Topics
- Alleles
- Base Sequence
- Chemoreceptor Cells
- DNA Primers
- Fungal Proteins
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- GTP-Binding Proteins
- Gene Expression
- Heterotrimeric GTP-Binding Proteins
- Mating Factor
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data
- Peptides
- Phenotype
- Pheromones
- Point Mutation
- Receptors, Cell Surface