Article
The third cytoplasmic loop of a yeast G-protein-coupled receptor controls pathway activation, ligand discrimination, and receptor internalization.
Molecular and cellular biology - 1 May 1994
Stefan C J, Blumer K J
Abstract excerpt
To identify functional domains of G-protein-coupled receptors that control pathway activation, ligand discrimination, and receptor regulation, we have used as a model the alpha-factor receptor (STE2 gene product) of the yeast Saccharomyces cerevisiae. From a collection of random mutations introdu...
Topics
- Alleles
- Amino Acid Sequence
- Genes, Fungal
- Genotype
- Kinetics
- Mating Factor
- Models, Structural
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Peptides
- Pheromones
- Plasmids
- Protein Structure, Secondary
- Receptors, Mating Factor
- Receptors, Peptide
- Saccharomyces
- Saccharomyces cerevisiae
- Schizosaccharomyces