Article
Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway.
The Journal of biological chemistry - 15 Apr 1993
Weiner J L, Guttierez-Steil C, Blumer K J
Abstract excerpt
In the yeast Saccharomyces cerevisiae, a G protein-linked signal transduction pathway mediates response to the oligopeptide mating pheromones a-factor and alpha-factor. Because cellular responses, including G1 arrest, occur transiently, cells can adapt or desensitize and resume growth. To address...
Topics
- Alleles
- Amino Acid Sequence
- Cell Membrane
- Endocytosis
- GTP-Binding Proteins
- Genes, Fungal
- Kinetics
- Mating Factor
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Peptides
- Protein Structure, Secondary
- Receptors, Cell Surface
- Receptors, Mating Factor
- Receptors, Peptide
- Saccharomyces cerevisiae
- Transcription Factors