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Article

Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway.

The Journal of biological chemistry - 15 Apr 1993

Weiner J L, Guttierez-Steil C, Blumer K J

Abstract excerpt

In the yeast Saccharomyces cerevisiae, a G protein-linked signal transduction pathway mediates response to the oligopeptide mating pheromones a-factor and alpha-factor. Because cellular responses, including G1 arrest, occur transiently, cells can adapt or desensitize and resume growth. To address whether the balance between response and adaptation is influenced by the efficiency of receptor-G protein interaction,...

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PMID: 8385135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway.PMID 8385135Read ↗

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Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Dominant-negative mutations in the G-protein-coupled alpha-factor receptor map to the extracellular ends of the transmembrane segments.Semantic proximity Read ↗

Functional and physical interactions among Saccharomyces cerevisiae α-factor receptors.Semantic proximity Read ↗

The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors.Semantic proximity Read ↗

Genetic fine-structural analysis of the Saccharomyces cerevisiae alpha-pheromone receptor.Semantic proximity Read ↗

Autocrine activation of the pheromone response pathway in matalpha2- cells is attenuated by SST2- and ASG7-dependent mechanisms.Semantic proximity Read ↗

Substitutions in the hydrophobic core of the alpha-factor receptor of Saccharomyces cerevisiae permit response to Saccharomyces kluyveri alpha-factor and to antagonist.Semantic proximity Read ↗

Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant.Semantic proximity Read ↗

A role for a complex between activated G protein-coupled receptors in yeast cellular mating.Semantic proximity Read ↗

Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.Semantic proximity Read ↗

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