Article
Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization.
The Journal of cell biology - 20 Apr 1998
Hicke L, Zanolari B, Riezman H
Abstract excerpt
G protein-coupled (GPC) receptors are phosphorylated in response to ligand binding, a modification that promotes receptor desensitization or downregulation. The alpha-factor pheromone receptor (Ste2p) of Saccharomyces cerevisiae is a GPC receptor that is hyperphosphorylated and ubiquitinated upon...
Topics
- Amino Acid Sequence
- Casein Kinases
- Cytoplasm
- Endocytosis
- Lysine
- Mating Factor
- Molecular Sequence Data
- Mutation
- Peptides
- Phosphorylation
- Protein Kinases
- Receptors, Mating Factor